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KMID : 1134820220510080765
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Journal of the Korean Society of Food Science and Nutrition
2022 Volume.51 No. 8 p.765 ~ p.779
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Effects of Moringa oleifera L. and Eucommia ulmoides Oliver Mixed Formula on Ligation-Induced Experimental Periodontitis and Alveolar Bone Loss in Rats
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Kim Tae-Gi
Park Mi-Ryeong
Ku Sae-Kwang
Heo Seok-Mo
Kim Jong-Lae
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Abstract
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Periodontitis is a chronic inflammatory disease characterized by destruction of the tooth-supporting connective tissue and cementum, bone resorption, leukocyte infiltration, and periodontal pocket formation. This study examined the dose-dependent inhibitory potential of the synergic mixed formula Moringa oleifera Lam. (MF) and Eucommia ulmoides Oliver (EC) 2:1 (w/w) on experimental periodontitis diseased rats, as compared to concentrations administered as single agents. This study was undertaken to develop potent mixed medicinal foods for preventing or treating periodontal diseases. One day after ligation placements, four different doses of the MF-EC mixed formula, and MF and EC single compounds were orally administered, for 10 days. We observed a decrease in the number of buccal gingival total aerobic bacteria. Moreover, the anti-inflammatory and anti-oxidative effects (reduced gingival myeloperoxidase and inducible nitric oxide synthase activities, prostaglandin E2, interleukin-1β, tumor necrosis factor-α, and malondialdehyde levels, numbers of inflammatory cells infiltrated in gingival tissues, decreased matrix metalloproteinase contents, increased collagen fiber occupied regions in gingival tissues, and favorable inhibitory effects on experimental periodontitis diseases related alveolar bone losses), decreases in the alveolar bone loss scores, receptor activator of nuclear factor kappa-B ligand/osteoprotegerin mRNA expressions, osteoclast cell numbers and activations, increased osteoblast cell numbers and activities, and increased alveolar bone volumes, were demonstrated after oral administration of the four different doses of the MF-EC mixed formula. All effects showed a doe-dependent trend. Taken together, these results indicate that the MF-EC mixed formula is a promising new potent protective or mixed medicinal food for relieving periodontitis and related alveolar bone loss.
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KEYWORD
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periodontitis, alveolar bone loss, anti-oxidant, anti-bacterial, anti-inflammatory effects
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